Intracranial pressure responsiveness to positive end-expiratory pressure is influenced by chest wall elastance: a physiological study in patients with aneurysmal subarachnoid hemorrhage.

ABSTRACT:

Background

Respiratory system elastance (E_RS) is an important determinant of the responsiveness of intracranial pressure (ICP) to positive end-expiratory pressure (PEEP). However, lung elastance (E_L) and chest wall elastance (E_CW) were not differentiated in previous studies. We tested the hypothesis that patients with high E_CW or a high E_CW/E_RS ratio have greater ICP responsiveness to PEEP.

Methods

An esophageal balloon catheter was placed to measure esophageal pressure. PEEP was increased from 5 to 15 cmH₂O. Airway pressure and esophageal pressure were measured and E_L, E_CW and E_RS were calculated at the two PEEP levels. Patients were classified into either an ICP re

SUBMITTER: Chen H 

PROVIDER: S-EPMC6108121 | biostudies-literature | 2018 Aug

REPOSITORIES: biostudies-literature