The association of HLA-C alleles with multiple myeloma in Chinese patients.

ABSTRACT:

Background

The positive association of multiple myeloma (MM) risk with HLA-C loci C*07:02 g and C*02:02 g, and the negative association of that with C*05:01 g were statistically significant in Whites have recently been reported. However, no association between HLA-C alleles and MM risk was found in Asians/Pacific Islanders. Here we identified 316 Chinese patients with MM, and reported the results of our investigation of HLA-C in MM in Chinese population.

Methods

We identified 316 Chinese patients with MM diagnosed in our hospital, and typed for HLA-C by using Sanger sequence-based typing. The control was from laboratories of China Marrow Donor Program (CMDP), where HLA high resolution was provided in 564,856 volunteer adult donors.

Results

In contrast to the associati

SUBMITTER: Wang X 

PROVIDER: S-EPMC6108132 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature