Hyaluronan-binding protein 2 (HABP2) gene variation in women with recurrent miscarriage.

ABSTRACT:

Background

Idiopathic recurrent miscarriage, defined as three or more consecutive miscarriages, is a distressing early pregnancy complication. Although, the etiology of recurrent miscarriage is still unknown, an aberrant regulation of the endometrial receptivity marker hyaluronan-binding protein 2 (HABP2) has been suggested. The objective of the present study was to investigate the effect of genetic variations of HABP2 in women with idiopathic recurrent miscarriage compared to fertile women.

Methods

This study was designed as a case-control study. In total, 165 women who had three or more consecutive miscarriages and 289 fertile women were included in the study. Polymorphisms in the HABP2 gene were analyzed using TaqMan SNP Genotyping Assays. Three polymorphisms in the HABP2

SUBMITTER: Husseini-Akram F 

PROVIDER: S-EPMC6108148 | biostudies-literature | 2018 Aug

REPOSITORIES: biostudies-literature