A single-cell atlas of the airway epithelium reveals the CFTR-rich pulmonary ionocyte.

ABSTRACT: The functions of epithelial tissues are dictated by the types, abundance and distribution of the differentiated cells they contain. Attempts to restore tissue function after damage require knowledge of how physiological tasks are distributed among cell types, and how cell states vary between homeostasis, injury-repair and disease. In the conducting airway, a heterogeneous basal cell population gives rise to specialized luminal cells that perform mucociliary clearance¹. Here we perform single-cell profiling of human bronchial epithelial cells and mouse tracheal epithelial cells to obtain a comprehensive census of cell types in the conducting airway and their behaviour in homeostasis and regeneration. Our analysis reveals cell states that represent known and novel cell populations

SUBMITTER: Plasschaert LW 

PROVIDER: S-EPMC6108322 | biostudies-literature | 2018 Aug

REPOSITORIES: biostudies-literature