Exposure to Polycyclic Aromatic Hydrocarbons and Accelerated DNA Methylation Aging.

ABSTRACT:

Background

Aging is related to an increased risk of morbidity and mortality and is affected by environmental factors. Exposure to polycyclic aromatic hydrocarbons (PAHs) is associated with adverse health outcomes; but the association of such exposure with DNA methylation aging, a novel aging marker, is unclear.

Objectives

Our aim was to investigate the association of PAH exposure with methylation aging.

Methods

We trained and validated a methylation age predictor suitable for Chinese populations using whole blood methylation data in 989 Chinese and 160 Caucasians. We defined two aging indicators: δage, as methylation age minus chronological age; and aging rate, the ratio of methylation to chronological age. The association of PAH exposure with aging indicators was eva

SUBMITTER: Li J 

PROVIDER: S-EPMC6108582 | biostudies-literature | 2018 Jun

REPOSITORIES: biostudies-literature