Traffic-Related Air Pollution, <i>APOE</i>ε4 Status, and Neurodevelopmental Outcomes among School Children Enrolled in the BREATHE Project (Catalonia, Spain).

ABSTRACT:

Background

Traffic-related air pollution is emerging as a risk factor for Alzheimer's disease (AD) and impaired brain development. Individual differences in vulnerability to air pollution may involve the ε4 allele of Apolipoprotein E (APOE) gene, the primary genetic risk factor for AD.

Objective

We analyzed whether the association between traffic air pollution and neurodevelopmental outcomes is modified by APOEε4 status in children.

Methods

Data on parent-reported behavior problems (total difficulties scores, Strengths and Difficulties Questionnaire), teacher-reported attention-deficit hyperactivity disorder (ADHD) symptom scores, cognitive performance trajectories (computerized tests of inattentiveness and working memory repeated 2-4 times during

SUBMITTER: Alemany S 

PROVIDER: S-EPMC6108838 | biostudies-literature | 2018 Aug

REPOSITORIES: biostudies-literature