Screening of circular RNAs and validation of circANKRD36 associated with inflammation in patients with type 2 diabetes mellitus.

ABSTRACT: Circular RNAs (circRNAs) are an abundant class of endogenous non‑coding RNAs and are associated with numerous diseases, including cancer, cardiovascular diseases, and type 2 diabetes mellitus (T2DM). However, the association between circRNAs and inflammation or inflammatory cytokines in patients with T2DM remains to be fully elucidated. The purpose of the present study was to investigate the expression profiles of circRNAs in peripheral leucocytes of patients with T2DM and their association with inflammatory cytokines. Peripheral blood from patients with T2DM (n=43) and healthy individuals (n=45) were collected for RNA sequencing and later verification. Reverse transcription‑polymerase chain reaction (RT‑PCR) and reverse transcription‑quantitative polymerase chain reaction (RT‑qPCR) analys

SUBMITTER: Fang Y 

PROVIDER: S-EPMC6108858 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature