Environmental reservoirs for exoS+ and exoU+ strains of Pseudomonas aeruginosa.

ABSTRACT: Pseudomonas aeruginosa uses its type III secretion system to inject the effector proteins ExoS and ExoU into eukaryotic cells, which subverts these cells to the bacterium's advantage and contributes to severe infections. We studied the environmental reservoirs of exoS+ and exoU+ strains of P. aeruginosa by collecting water, soil, moist substrates and plant samples from environments in the Chicago region and neighbouring states. Whole-genome sequencing was used to determine the phylogeny and type III secretion system genotypes of 120 environmental isolates. No correlation existed between geographic separation of isolates and their genetic relatedness, which confirmed previous findings of both high genetic diversity within a single site and the widespread distribution of P. aeruginosa clonal

SUBMITTER: Rutherford V 

PROVIDER: S-EPMC6108916 | biostudies-literature | 2018 Aug

REPOSITORIES: biostudies-literature