Intra-individual alterations of serum markers routinely used in forensic pathology depending on increasing post-mortem interval.

ABSTRACT: Post-mortem biochemistry of serum markers has been the subject of numerous studies, but in-situ marker stability after death has not been sufficiently evaluated yet. Such laboratory analyses are especially necessary in the cases of functional deaths without morphological evidence of the death causes and also in cardiac death cases with only very short survival times. The aim of the study was to determine the post-mortem stability of commonly-used serum markers at predefined time points. In 20 cases, peripheral venous samples were taken starting immediately after circulatory arrest and ending 48 hours after death. Serum creatinine, urea, 3-β-hydroxybutyrate, tryptase, myoglobin, troponin T, creatin kinase and creatin kinase-MB have been included. For all markers, we observed increasing mark

SUBMITTER: Woydt L 

PROVIDER: S-EPMC6109050 | biostudies-literature | 2018 Aug

REPOSITORIES: biostudies-literature