PR-LncRNA signature regulates glioma cell activity through expression of SOX factors.
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ABSTRACT:
SUBMITTER: Torres-Bayona S
PROVIDER: S-EPMC6109087 | biostudies-literature | 2018 Aug
REPOSITORIES: biostudies-literature
Publications
PR-LncRNA signature regulates glioma cell activity through expression of SOX factors.
Torres-Bayona Sergio S Aldaz Paula P Auzmendi-Iriarte Jaione J Saenz-Antoñanzas Ander A Garcia Idoia I Arrazola Mariano M Gerovska Daniela D Undabeitia Jose J Querejeta Arrate A Egaña Larraitz L Villanúa Jorge J Ruiz Irune I Sarasqueta Cristina C Urculo Enrique E Araúzo-Bravo Marcos J MJ Huarte Maite M Samprón Nicolas N Matheu Ander A
Scientific reports 20180824 1
Long non-coding RNAs (LncRNAs) have emerged as a relevant class of genome regulators involved in a broad range of biological processes and with important roles in tumor initiation and malignant progression. We have previously identified a p53-regulated tumor suppressor signature of LncRNAs (PR-LncRNAs) in colorectal cancer. Our aim was to identify the expression and function of this signature in gliomas. We found that the expression of the four PR-LncRNAs tested was high in human low-grade gliom ...[more]
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