Characterization and induction of prophages in human gut-associated Bifidobacterium hosts.

ABSTRACT: In the current report, we describe the identification of three genetically distinct groups of prophages integrated into three different chromosomal sites of human gut-associated Bifidobacterium breve and Bifidobacterium longum strains. These bifidobacterial prophages are distantly related to temperate actinobacteriophages of several hosts. Some prophages, integrated within the dnaJ₂ gene, are competent for induction, excision, replication, assembly and lysis, suggesting that they are fully functional and can generate infectious particles, even though permissive hosts have not yet been identified. Interestingly, several of these phages harbor a putative phase variation shufflon (the Rin system) that generates variation of the tail-associated receptor binding protein (RBP). Unlike

SUBMITTER: Mavrich TN 

PROVIDER: S-EPMC6109161 | biostudies-literature | 2018 Aug

REPOSITORIES: biostudies-literature