Ontology highlight
ABSTRACT:
SUBMITTER: Quintana-Cabrera R
PROVIDER: S-EPMC6109181 | biostudies-literature | 2018 Aug
REPOSITORIES: biostudies-literature
Nature communications 20180824 1
It is unclear how the mitochondrial fusion protein Optic atrophy 1 (OPA1), which inhibits cristae remodeling, protects from mitochondrial dysfunction. Here we identify the mitochondrial F<sub>1</sub>F<sub>o</sub>-ATP synthase as the effector of OPA1 in mitochondrial protection. In OPA1 overexpressing cells, the loss of proton electrochemical gradient caused by respiratory chain complex III inhibition is blunted and this protection is abolished by the ATP synthase inhibitor oligomycin. Mechanisti ...[more]