Identification of beagle food taking patterns and protocol for food effects evaluation on bioavailability.

ABSTRACT: Food is a known primary role to the exposure of the drugs orally administered. Since each animal may have unique food taking pattern and it is difficult to manipulate the food taking to animals, there lacks rationalized protocol for the food effects in pre-clinic study. The objective of this study was to identify the beagle food taking patterns and demonstrate their effects on bioavailability in valsartan. Herein, four types of food taking patterns of beagle were identified via inter-day and intra-day analysis, and named as Persisting, Pulsing, Postponing, Pushing ("4P Modes"), respectively, which were also validated by principal component analysis (PCA). Interestingly, food intake resulted in a reduced area under the concentration-time curve (AUC_0-12h), maximum concentration (C

SUBMITTER: Zhang G 

PROVIDER: S-EPMC6109188 | biostudies-literature | 2018 Aug

REPOSITORIES: biostudies-literature