Selegiline reduces adiposity induced by high-fat, high-sucrose diet in male rats.

ABSTRACT:

Background and purpose

Incidence and severity of obesity are increasing worldwide, however, efficient and safe pharmacological treatments are not yet available. Certain MAO inhibitors reduce body weight, although their effects on metabolic parameters have not been investigated. Here, we have assessed effects of a widely used, selective MAO-B inhibitor, selegiline, on metabolic parameters in a rat model of diet-induced obesity.

Experimental approach

Male Long-Evans rats were given control (CON) or a high-fat (20%), high-sucrose (15%) diet (HFS) for 25 weeks. From week 16, animals were injected s.c. with 0.25 mg·kg^-1 selegiline (CON + S and HFS + S) or vehicle (CON, HFS) once daily. Whole body, subcutaneous and visceral fat was measured by CT, and glucose and insuli

SUBMITTER: Nagy CT 

PROVIDER: S-EPMC6109222 | biostudies-literature | 2018 Sep

REPOSITORIES: biostudies-literature