Dysbiosis of maternal and neonatal microbiota associated with gestational diabetes mellitus.

ABSTRACT:

Objective

The initial colonisation of the human microbiota and the impact of maternal health on neonatal microbiota at birth remain largely unknown. The aim of our study is to investigate the possible dysbiosis of maternal and neonatal microbiota associated with gestational diabetes mellitus (GDM) and to estimate the potential risks of the microbial shift to neonates.

Design

Pregnant women and neonates suffering from GDM were enrolled and 581 maternal (oral, intestinal and vaginal) and 248 neonatal (oral, pharyngeal, meconium and amniotic fluid) samples were collected. To avoid vaginal bacteria contaminations, the included neonates were predominantly delivered by C-section, with their samples collected within seconds of delivery.

Results

Numerous and diverse bacterial

SUBMITTER: Wang J 

PROVIDER: S-EPMC6109274 | biostudies-literature | 2018 Sep

REPOSITORIES: biostudies-literature