The British Society of Gastroenterology/UK-PBC primary biliary cholangitis treatment and management guidelines.

ABSTRACT: Primary biliary cholangitis (formerly known as primary biliary cirrhosis, PBC) is an autoimmune liver disease in which a cycle of immune mediated biliary epithelial cell injury, cholestasis and progressive fibrosis can culminate over time in an end-stage biliary cirrhosis. Both genetic and environmental influences are presumed relevant to disease initiation. PBC is most prevalent in women and those over the age of 50, but a spectrum of disease is recognised in adult patients globally; male sex, younger age at onset (<45) and advanced disease at presentation are baseline predictors of poorer outcome. As the disease is increasingly diagnosed through the combination of cholestatic serum liver tests and the presence of antimitochondrial antibodies, most presenting patients are not cirrhotic an

SUBMITTER: Hirschfield GM 

PROVIDER: S-EPMC6109281 | biostudies-literature | 2018 Sep

REPOSITORIES: biostudies-literature