Association of tamoxifen resistance and lipid reprogramming in breast cancer.

ABSTRACT:

Background

Tamoxifen treatment of estrogen receptor (ER)-positive breast cancer reduces mortality by 31%. However, over half of advanced ER-positive breast cancers are intrinsically resistant to tamoxifen and about 40% will acquire the resistance during the treatment.

Methods

In order to explore mechanisms underlying endocrine therapy resistance in breast cancer and to identify new therapeutic opportunities, we created tamoxifen-resistant breast cancer cell lines that represent the luminal A or the luminal B. Gene expression patterns revealed by RNA-sequencing in seven tamoxifen-resistant variants were compared with their isogenic parental cells. We further examined those transcriptomic alterations in a publicly available patient cohort.

Results

We show that tamoxifen

SUBMITTER: Hultsch S 

PROVIDER: S-EPMC6109356 | biostudies-literature | 2018 Aug

REPOSITORIES: biostudies-literature