Action potential initiation, propagation, and cortical invasion in the hyperdirect pathway during subthalamic deep brain stimulation.

ABSTRACT:

Background

High frequency (∼130 Hz) deep brain stimulation (DBS) of the subthalamic region is an established clinical therapy for the treatment of late stage Parkinson's disease (PD). Direct modulation of the hyperdirect pathway, defined as cortical layer V pyramidal neurons that send an axon collateral to the subthalamic nucleus (STN), has emerged as a possible component of the therapeutic mechanisms. However, numerous questions remain to be addressed on the basic biophysics of hyperdirect pathway stimulation.

Objective

Quantify action potential (AP) initiation, propagation, and cortical invasion in hyperdirect neurons during subthalamic stimulation.

Methods

We developed an anatomically and electrically detailed computational model of hyperdirect neuron stimulation w

SUBMITTER: Anderson RW 

PROVIDER: S-EPMC6109410 | biostudies-literature | 2018 Sep - Oct

REPOSITORIES: biostudies-literature