Biosynthesis of D-Series Resolvins in Skin Provides Insights into their Role in Tissue Repair.

ABSTRACT: Cutaneous injury causes underlying tissue damage that must be quickly repaired to minimize exposure to pathogens and to restore barrier function. While the role of growth factors in tissue repair is established, the role of lipid mediators in skin repair has not been investigated extensively. Using a mass spectrometry-based lipid mediator metabolomics approach, we identified D-series resolvins and related pro-resolving lipid mediators during skin injury in mice and pigs. Differentiation of human epidermal keratinocytes increased expression of 15-lipoxygenase and stereospecific production of 17S-hydroxydocosahexaenoic acid, the common upstream biosynthetic marker and precursor of D-series resolvins. In human and pig skin, specific receptors for D-series resolvins were expressed in the epide

SUBMITTER: Hellmann J 

PROVIDER: S-EPMC6109422 | biostudies-literature | 2018 Sep

REPOSITORIES: biostudies-literature