Determinants of Outcomes of Adenoviral Keratoconjunctivitis.

ABSTRACT:

Purpose

To determine host and pathogen factors predictive of outcomes in a large clinical cohort with keratoconjunctivitis.

Design

Retrospective analyses of the clinical and molecular data from a randomized, controlled, masked trial for auricloscene for keratoconjunctivitis (NVC-422 phase IIB, NovaBay; clinicaltrials.gov identifier, NCT01877694).

Participants

Five hundred participants from United States, India, Brazil, and Sri Lanka with clinical diagnosis of keratoconjunctivitis and positive rapid test results for adenovirus.

Methods

Clinical signs and symptoms and bilateral conjunctival swabs were obtained on days 1, 3, 6, 11, and 18. Polymerase chain reaction (PCR) analysis was performed to detect and quantify adenovirus in all samples. Regression models wer

SUBMITTER: Lee CS 

PROVIDER: S-EPMC6109430 | biostudies-literature | 2018 Sep

REPOSITORIES: biostudies-literature