Bacterial secretion chaperones: the mycobacterial type VII case.

ABSTRACT: Chaperones are central players in maintaining the proteostasis in all living cells. Besides highly conserved generic chaperones that assist protein folding and assembly in the cytosol, additional more specific chaperones have evolved to ensure the successful trafficking of proteins with extra-cytoplasmic locations. Associated with the distinctive secretion systems present in bacteria, different dedicated chaperones have been described that not only keep secretory proteins in a translocation competent state, but often are also involved in substrate targeting to the specific translocation channel. Recently, a new class of such chaperones has been identified that are involved in the specific recognition of substrates transported via the type VII secretion pathway in mycobacteria. In this mini

SUBMITTER: Phan TH 

PROVIDER: S-EPMC6109436 | biostudies-literature | 2018 Sep

REPOSITORIES: biostudies-literature