The Impact of Purinergic System Enzymes on Noncommunicable, Neurological, and Degenerative Diseases.

ABSTRACT: Evidences show that purinergic signaling is involved in processes associated with health and disease, including noncommunicable, neurological, and degenerative diseases. These diseases strike from children to elderly and are generally characterized by progressive deterioration of cells, eventually leading to tissue or organ degeneration. These pathological conditions can be associated with disturbance in the signaling mediated by nucleotides and nucleosides of adenine, in expression or activity of extracellular ectonucleotidases and in activation of P2X and P2Y receptors. Among the best known of these diseases are atherosclerosis, hypertension, cancer, epilepsy, Alzheimer's disease (AD), Parkinson's disease (PD), and multiple sclerosis (MS). The currently available treatments present limit

SUBMITTER: Bagatini MD 

PROVIDER: S-EPMC6109496 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature