Gut-microbiome-related LCT genotype and 2-year changes in body composition and fat distribution: the POUNDS Lost Trial.

ABSTRACT:

Background/objectives

Gut microbiome regulates host energy metabolism and adiposity. A recent study identified a genome-wide significant variant in the lactase (LCT) gene that determines gut-microbiome abundance. We investigated whether the LCT variant influenced long-term changes in adiposity among overweight and obese individuals.

Subjects/methods

We included 583 whites with LCT variant rs4988235 (G allele as Bifidobacterium-abundance-increasing allele) who were randomly assigned to one of four weight-loss diets varying in macronutrient contents. Two-year changes in adiposity measures were assessed according to the LCT genotype and weight-loss diets.

Results

We observed a significant interaction between the LCT genotype and dietary protein intake on changes in whole

SUBMITTER: Heianza Y 

PROVIDER: S-EPMC6109621 | biostudies-literature | 2018 Sep

REPOSITORIES: biostudies-literature