Targeting the MMP-14/MMP-2/integrin α_vβ₃ axis with multispecific N-TIMP2-based antagonists for cancer therapy.

ABSTRACT: The pathophysiological functions of the signaling molecules matrix metalloproteinase-14 (MMP-14) and integrin α_vβ₃ in various types of cancer are believed to derive from their collaborative activity in promoting invasion, metastasis, and angiogenesis, as shown in vitro and in vivo The two effectors act in concert in a cell-specific manner through the localization of pro-MMP-2 to the cell surface, where it is processed to intermediate and matured MMP-2. The matured MMP-2 product is localized to the cell surface via its binding to integrin α_vβ₃ The MMP-14/MMP-2/integrin α_vβ₃ axis thus constitutes an attractive putative target for therapeutic interventions, but the development of inhibitors that target this axis r

SUBMITTER: Yosef G 

PROVIDER: S-EPMC6109916 | biostudies-literature | 2018 Aug

REPOSITORIES: biostudies-literature