Trauma exposure interacts with the genetic risk of bipolar disorder in alcohol misuse of US soldiers.

ABSTRACT:

Objective

To investigate whether trauma exposure moderates the genetic correlation between substance use disorders and psychiatric disorders, we tested whether trauma exposure modifies the association of genetic risks for mental disorders with alcohol misuse and nicotine dependence (ND) symptoms.

Methods

High-resolution polygenic risk scores (PRSs) were calculated for 10 732 US Army soldiers (8346 trauma-exposed and 2386 trauma-unexposed) based on genome-wide association studies of bipolar disorder (BD), major depressive disorder, and schizophrenia.

Results

The main finding was a significant BD PRS-by-trauma interaction with respect to alcohol misuse (P = 6.07 × 10^-3 ). We observed a positive correlation between BD PRS and alcohol misuse in trauma-exposed s

SUBMITTER: Polimanti R 

PROVIDER: S-EPMC6110087 | biostudies-literature | 2018 Feb

REPOSITORIES: biostudies-literature