In vivo Biodistribution of Radiolabeled Acoustic Protein Nanostructures.

ABSTRACT:

Purpose

Contrast-enhanced ultrasound plays an expanding role in oncology, but its applicability to molecular imaging is hindered by a lack of nanoscale contrast agents that can reach targets outside the vasculature. Gas vesicles (GVs)-a unique class of gas-filled protein nanostructures-have recently been introduced as a promising new class of ultrasound contrast agents that can potentially access the extravascular space and be modified for molecular targeting. The purpose of the present study is to determine the quantitative biodistribution of GVs, which is critical for their development as imaging agents.

Procedures

We use a novel bioorthogonal radiolabeling strategy to prepare technetium-99m-radiolabeled ([^99mTc])GVs in high radiochemical purity. We use single p

SUBMITTER: Le Floc'h J 

PROVIDER: S-EPMC6110388 | biostudies-literature | 2018 Apr

REPOSITORIES: biostudies-literature