Investigating Dependencies of Relative Biological Effectiveness for Proton Therapy in Cancer Cells.

ABSTRACT:

Purpose

Relative biological effectiveness (RBE) accounts for the differences in biological effect from different radiation types. The RBE for proton therapy remains uncertain, as it has been shown to vary from the clinically used value of 1.1. In this work we investigated the RBE of protons and correlated the biological differences with the underlying physical quantities.

Materials and methods

Three cell lines were irradiated (CHO, Chinese hamster ovary; A549, human lung adenocarcinoma; and T98, human glioma) and assessed for cell survival by using clonogenic assay. Cells were irradiated with 71- and 160-MeV protons at depths along the Bragg curve and 6-MV photons to various doses. The dose-averaged lineal energy ( y‒D ) was measured under similar conditions as the cells by

SUBMITTER: Howard ME 

PROVIDER: S-EPMC6110616 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature