Association between polymorphisms in SLC15A1 and PLA2G16 genes and development of obesity in Chinese subjects.

ABSTRACT:

Introduction

The small peptide transporter 1 (PepT-1) and adipose phospholipase A2 (AdPLA) play a key role in the development of obesity. However, there are no data assessing the impact of PepT-1 (SLC15A1) and AdPLA (PLA2G16) variants on obesity susceptibility. Therefore, we assessed the contribution of 9 single-nucleotide polymorphisms (SNPs) between these two genes on obesity susceptibility in Chinese subjects.

Materials and methods

A total of 611 participants were enrolled in the study, and 9 SNPs in the SLC15A1 and PLA2G16 genes were selected. Blood samples were collected for genotyping. Overweight and obesity were established by body mass index. Regression analyses were performed to test for any association of genetic polymorphisms with weigh

SUBMITTER: Wang CY 

PROVIDER: S-EPMC6110659 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature