Visualizing the hydrodynamics in sieve-based lateral displacement systems.

ABSTRACT: Deterministic lateral displacement (DLD) systems structure suspension flow in so called flow lanes. The width of these flow lanes is crucial for separation of particles and determines whether particles with certain size are displaced or not. In previous research, separation was observed in simplified DLD systems that did not meet the established DLD geometric design criteria, by adjusting the outflow conditions. We here investigated why these simplified DLD systems are able to displace particles, by experimentally investigating the hydrodynamics in the device. Flow lanes were visualized and the local flow velocities were measured using µPIV and compared with 2D fluid dynamics simulations. The size of the flow lanes strongly correlates with the local flow velocity (V_y and V_x

SUBMITTER: Dijkshoorn JP 

PROVIDER: S-EPMC6110767 | biostudies-literature | 2018 Aug

REPOSITORIES: biostudies-literature