GYY4137 Promotes Mice Feeding Behavior via Arcuate Nucleus Sulfur-Sulfhydrylation and AMPK Activation.

ABSTRACT: Hydrogen sulfide (H₂S) is an endogenous gaseous molecule and plays important biological and neurochemical roles in many processes such as the neural activity and immunity. The arcuate nucleus (ARC) of hypothalamus is a control center for appetite and energy metabolism. AMPK is a gage kinase in the monitoring of energy status and regulation of energy metabolism, and it can be activated by H₂S via CaMKKβ/AMPK pathway. But the role of H₂S in ARC and appetite has not been reported. Here we studied the orexigenic effect of H₂S and the mechanisms by means of GYY4137, a water soluble and slow-releasing donor of H₂S, and protein sulfur-sulfhydrylation analysis. We demonstrated that GYY4137-derived H₂S increased food intake of mice,

SUBMITTER: Zhou J 

PROVIDER: S-EPMC6111581 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature