Cognitive Reserve Relates to Functional Network Efficiency in Alzheimer's Disease.

ABSTRACT: Alzheimer's disease (AD) is the most common form of dementia, with no means of cure or prevention. The presence of abnormal disease-related proteins in the population is, in turn, much more common than the incidence of dementia. In this context, the cognitive reserve (CR) hypothesis has been proposed to explain the discontinuity between pathophysiological and clinical expression of AD, suggesting that CR mitigates the effects of pathology on clinical expression and cognition. fMRI studies of the human connectome have recently reported that AD patients present diminished functional efficiency in resting-state networks, leading to a loss in information flow and cognitive processing. No study has investigated, however, whether CR modifies the effects of the pathology in functional network eff

SUBMITTER: Weiler M 

PROVIDER: S-EPMC6111617 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature