Actin cytoskeleton assembly regulates collagen production via TGF-β type II receptor in human skin fibroblasts.

ABSTRACT: The dermal compartment of skin is primarily composed of collagen-rich extracellular matrix (ECM), which is produced by dermal fibroblasts. In Young skin, fibroblasts attach to the ECM through integrins. During ageing, fragmentation of the dermal ECM limits fibroblast attachment. This reduced attachment is associated with decreased collagen production, a major cause of skin thinning and fragility, in the elderly. Fibroblast attachment promotes assembly of the cellular actin cytoskeleton, which generates mechanical forces needed for structural support. The mechanism(s) linking reduced assembly of the actin cytoskeleton to decreased collagen production remains unclear. Here, we report that disassembly of the actin cytoskeleton results in impairment of TGF-β pathway, which controls collagen pr

SUBMITTER: Qin Z 

PROVIDER: S-EPMC6111811 | biostudies-literature | 2018 Sep

REPOSITORIES: biostudies-literature