The involvement of Toll-like receptor 9 in the pathogenesis of erosive autoimmune arthritis.

ABSTRACT: Endogenous nucleic acids and their receptors may be involved in the initiation of systemic autoimmune diseases including rheumatoid arthritis (RA). As the role of the DNA sensing Toll-like receptor (TLR) 9 in RA is unclear, we aimed to investigate its involvement in the pathogenesis of autoimmune arthritis using three different experimental models of RA. The data obtained revealed involvement of TLR9 in the T cell-dependent phase of inflammatory arthritis. In rats with pristane-induced arthritis (PIA), TLR9 inhibition before disease onset reduced arthritis significantly and almost completely abolished bone erosion. Accordingly, serum levels of IL-6, α-1-acid-glycoprotein and rheumatoid factor were reduced. Moreover, in TLR9^-/- mice, streptococcal cell wall (SCW)-induced arthriti

SUBMITTER: Fischer A 

PROVIDER: S-EPMC6111819 | biostudies-literature | 2018 Sep

REPOSITORIES: biostudies-literature