Characterization of Three Small Proteins in Brucella abortus Linked to Fucose Utilization.

ABSTRACT: Elucidating the function of proteins <50 amino acids in length is no small task. Nevertheless, small proteins can play vital roles in the lifestyle of bacteria and influence the virulence of pathogens; thus, the investigation of the small proteome is warranted. Recently, our group identified the Brucella abortus protein VtlR as a transcriptional activator of four genes, one of which is the well-studied small regulatory RNA AbcR2, while the other three genes encode hypothetical small proteins, two of which are highly conserved among the order Rhizobiales This study provides evidence that all three genes encode authentic small proteins and that all three are highly expressed under oxidative stress, low-pH, and stationary-phase growth conditions. Fractionation of the cells revea

SUBMITTER: Budnick JA 

PROVIDER: S-EPMC6112010 | biostudies-literature | 2018 Sep

REPOSITORIES: biostudies-literature