A Next-Generation Sequencing-Based Molecular Approach to Characterize a Tick Vector in Lyme Disease.

ABSTRACT: Next-generation sequencing approaches have revolutionized genomic medicine and enabled rapid diagnosis for several diseases. These approaches are widely used for pathogen detection in several infectious diseases. Lyme disease is a tick-borne infectious disease, which affects multiple organs. The causative organism is a spirochete, Borrelia burgdorferi, which is transmitted by ticks. Lyme disease can be treated easily if detected early, but its diagnosis is often delayed or is incorrect leading to a chronic debilitating condition. Current confirmatory diagnostic tests for Lyme disease rely on detection of antigens derived from B. burgdorferi, which are prone to both false positives and false negatives. Instead of focusing only on the human host for the diagnosis of Lyme disease, one could a

SUBMITTER: Madugundu AK 

PROVIDER: S-EPMC6112187 | biostudies-literature | 2018 Aug

REPOSITORIES: biostudies-literature