Identification of proresolving and inflammatory lipid mediators in human psoriasis.

ABSTRACT:

Background

Psoriasis (PSO) is an immune-mediated inflammatory disease associated with metabolic and cardiovascular comorbidities. It is now known that resolution of inflammation is an active process locally controlled by specialized proresolving mediators (SPMs), named resolvins (Rvs), protectins, and maresins.

Objective

It is unknown whether these potent lipid mediators (LMs) are involved in PSO pathophysiology and if the skin and blood have disease-specific SPMs phenotype profiles.

Methods

We used liquid chromatography-tandem mass spectrometry-based LM metabololipidomics to obtain skin and peripheral blood LM profiles from PSO compared to healthy subjects. Some LMs were tested in cell culture experiments with corresponding gene expression and protein concentration a

SUBMITTER: Sorokin AV 

PROVIDER: S-EPMC6112609 | biostudies-literature | 2018 Jul - Aug

REPOSITORIES: biostudies-literature