3D Jet Writing: Functional Microtissues Based on Tessellated Scaffold Architectures.

ABSTRACT: The advent of adaptive manufacturing techniques supports the vision of cell-instructive materials that mimic biological tissues. 3D jet writing, a modified electrospinning process reported herein, yields 3D structures with unprecedented precision and resolution offering customizable pore geometries and scalability to over tens of centimeters. These scaffolds support the 3D expansion and differentiation of human mesenchymal stem cells in vitro. Implantation of these constructs leads to the healing of critical bone defects in vivo without exogenous growth factors. When applied as a metastatic target site in mice, circulating cancer cells home in to the osteogenic environment simulated on 3D jet writing scaffolds, despite implantation in an anatomically abnormal site. Through 3D jet writing,

SUBMITTER: Jordahl JH 

PROVIDER: S-EPMC6112611 | biostudies-literature | 2018 Apr

REPOSITORIES: biostudies-literature