Influence of puberty timing on adiposity and cardiometabolic traits: A Mendelian randomisation study.

ABSTRACT:

Background

Earlier puberty is widely linked with future obesity and cardiometabolic disease. We examined whether age at puberty onset likely influences adiposity and cardiometabolic traits independent of childhood adiposity.

Methods and findings

One-sample Mendelian randomisation (MR) analyses were conducted on up to 3,611 white-European female and male offspring from the Avon Longitudinal Study of Parents and Children (ALSPAC) cohort recruited at birth via mothers between 1 April 1991 and 31 December 1992. Time-sensitive exposures were age at menarche and age at voice breaking. Outcomes measured at age 18 y were body mass index (BMI), dual-energy X-ray absorptiometry-based fat and lean mass indices, blood pressure, and 230 cardiometabolic traits derived from targeted metabo

SUBMITTER: Bell JA 

PROVIDER: S-EPMC6112630 | biostudies-literature | 2018 Aug

REPOSITORIES: biostudies-literature