ABC transportome inventory of human pathogenic yeast Candida glabrata: Phylogenetic and expression analysis.

ABSTRACT: ATP-binding cassette (ABC) is one of the two major superfamilies of transporters present across the evolutionary scale. ABC superfamily members came to prominence due to their ability to extrude broad spectrum of substrates and to confer multi drug resistance (MDR). Overexpression of some ABC transporters in clinical isolates of Candida species was attributed to the development of MDR phenotypes. Among Candida species, Candida glabrata is an emerging drug resistant species in human fungal infections. A comprehensive analysis of such proteins in C. glabrata is required to untangle their role not only in MDR but also in other biological processes. Bioinformatic analysis of proteins encoded by genome of human pathogenic yeast C. glabrata identified 25 putative ABC protein coding genes. On the

SUBMITTER: Kumari S 

PROVIDER: S-EPMC6112666 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature