Silodosin versus tamsulosin for medical expulsive treatment of ureteral stones: A systematic review and meta-analysis.

ABSTRACT: Silodosin, a recently introduced selective α-blocker, has a much higher selectivity for the α-1A receptor. The efficacy and safety of silodosin compared to tamsulosin in medical expulsive therapy (MET) are controversial. The objective of this study was to assess the efficacy and safety of silodosin compared to tamsulosin for treating ureteral stones <10 mm in diameter. We systematically searched the PubMed, EMBASE, Cochrane library, and Scopus databases from their inception to May 2018. We included randomized controlled studies (RCTs) and observational studies, which investigated stone expulsion rates using silodosin compared to tamsulosin. Data were synthesized using a random-effects model. Sixteen studies with 1824 patients were eligible for inclusion. Silodosin achieved significantly hi

SUBMITTER: Hsu YP 

PROVIDER: S-EPMC6112672 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature