MimicrEE2: Genome-wide forward simulations of Evolve and Resequencing studies.

ABSTRACT: Evolve and Resequencing (E&R) studies allow us to monitor adaptation at the genomic level. By sequencing evolving populations at regular time intervals, E&R studies promise to shed light on some of the major open questions in evolutionary biology such as the repeatability of evolution and the molecular basis of adaptation. However, data interpretation, statistical analysis and the experimental design of E&R studies increasingly require simulations of evolving populations, a task that is difficult to accomplish with existing tools, which may i) be too slow, ii) require substantial reformatting of data, iii) not support an adaptive scenario of interest or iv) not sufficiently capture the biology of the used model organism. Therefore we developed MimicrEE2, a multi-threaded Java program for g

SUBMITTER: Vlachos C 

PROVIDER: S-EPMC6112681 | biostudies-literature | 2018 Aug

REPOSITORIES: biostudies-literature