Casz1 controls higher-order nuclear organization in rod photoreceptors.

ABSTRACT: Genome organization plays a fundamental role in the gene-expression programs of numerous cell types, but determinants of higher-order genome organization are poorly understood. In the developing mouse retina, rod photoreceptors represent a good model to study this question. They undergo a process called "chromatin inversion" during differentiation, in which, as opposed to classic nuclear organization, heterochromatin becomes localized to the center of the nucleus and euchromatin is restricted to the periphery. While previous studies showed that the lamin B receptor participates in this process, the molecular mechanisms regulating lamina function during differentiation remain elusive. Here, using conditional genetics, we show that the zinc finger transcription factor Casz1 is required to es

SUBMITTER: Mattar P 

PROVIDER: S-EPMC6112687 | biostudies-literature | 2018 Aug

REPOSITORIES: biostudies-literature