Third DWF1 paralog in Solanaceae, sterol Δ²⁴-isomerase, branches withanolide biosynthesis from the general phytosterol pathway.

ABSTRACT: A large part of chemodiversity of plant triterpenes is due to the modification of their side chains. Reduction or isomerization of double bonds in the side chains is often an important step for the diversification of triterpenes, although the enzymes involved are not fully understood. Withanolides are a large group of structurally diverse C₂₈ steroidal lactones derived from 24-methylenecholesterol. These compounds are found in the Indian medicinal plant Withania somnifera, also known as ashwagandha, and other members of the Solanaceae. The pathway for withanolide biosynthesis is unknown, preventing sustainable production via white biotechnology and downstream pharmaceutical usages. In the present study, based on genome and transcriptome data we have identified a key enzym

SUBMITTER: Knoch E 

PROVIDER: S-EPMC6112714 | biostudies-literature | 2018 Aug

REPOSITORIES: biostudies-literature