Altered formation of the iron oxide nanoparticle-biocorona due to individual variability and exercise.

ABSTRACT: Nanoparticles (NPs), introduced into a biological environment, accumulate a coating of biomolecules or biocorona (BC). Although the BC has toxicological and pharmacological consequences, the effects of inter-individual variability and exercise on NP-BC formation are unknown. We hypothesized that NPs incubated in plasma form distinct BCs between individuals, and exercise causes additional intra-individual alterations. 20 nm iron oxide (Fe₃O₄) NPs were incubated in pre- or post-exercise plasma ex vivo, and proteomics was utilized to evaluate BC components. Analysis demonstrated distinct BC formation between individuals, while exercise was found to enhance NP-BC complexity. Abundance differences of NP-BC proteins were determined between individuals and resulting from exe

SUBMITTER: Kobos LM 

PROVIDER: S-EPMC6112769 | biostudies-literature | 2018 Sep

REPOSITORIES: biostudies-literature