Metabolomic analysis of uterine serous carcinoma with acquired resistance to paclitaxel.

ABSTRACT:

Introduction

Uterine serous carcinoma (USC) is more aggressive than other subtypes of endometrial carcinoma and is associated with a poor prognosis. We analyzed the metabolomic profile of USC with acquired resistance to paclitaxel.

Results

Glutathione (GSH) concentration in PTX-1 cells was higher than in USPC-1 cells. In addition, GSH concentration in the USPC-1 cells increased after treatment with paclitaxel but was unchanged in PTX-1 cells. Glucose-6-phosphate (G6P) and ribose-5-phosphate (R5P) concentrations in PTX-1 cells were higher than those in USPC-1 cells. G6P concentration in the USPC-1 cells was unchanged after treatment with paclitaxel, while it decreased in PTX-1 cells.

Conclusion

Our results indicate that increased GSH and glucose metabolism may be relat

SUBMITTER: Seino M 

PROVIDER: S-EPMC6112827 | biostudies-literature | 2018 Aug

REPOSITORIES: biostudies-literature