The efficacy and safety of first-line therapies for preventing chronic post-surgical pain: a network meta-analysis.

ABSTRACT:

Background

Due to conflicting evidence regarding first-line therapies for chronic post-surgical pain (CPSP), here we comparatively evaluated the efficacy and safety of first-line therapies for the prevention of CPSP.

Materials and methods

MEDLINE, EMBASE, and Cochrane CENTRAL databases were searched for randomized, controlled trials (RCTs) of systemic drugs measuring pain three months or more post-surgery. Pairwise meta-analyses (a frequentist technique directly comparing each intervention against placebo) and network meta-analyses (a Bayesian technique simultaneously comparing several interventions via an evidence network) compared the mean differences for primary efficacy (reduction in all pain), secondary efficacy (reduction in moderate or severe pain), and primary safety

SUBMITTER: Ning J 

PROVIDER: S-EPMC6112831 | biostudies-literature | 2018 Aug

REPOSITORIES: biostudies-literature