A catenin-dependent balance between N-cadherin and E-cadherin controls neuroectodermal cell fate choices.

ABSTRACT: Characterizing endogenous protein expression, interaction and function, this study identifies in vivo interactions and competitive balance between N-cadherin and E-cadherin in developing avian (Gallus gallus) neural and neural crest cells. Numerous cadherin proteins, including neural cadherin (Ncad) and epithelial cadherin (Ecad), are expressed in the developing neural plate as well as in neural crest cells as they delaminate from the newly closed neural tube. To clarify independent or coordinate function during development, we examined their expression in the cranial region. The results revealed surprising overlap and distinct localization of Ecad and Ncad in the neural tube. Using a proximity ligation assay and co-immunoprecipitation, we found that Ncad and Ecad formed heterotypic comple

SUBMITTER: Rogers CD 

PROVIDER: S-EPMC6112866 | biostudies-literature | 2018 Aug

REPOSITORIES: biostudies-literature