Altered exocrine function can drive adipose wasting in early pancreatic cancer.

ABSTRACT: Malignancy is accompanied by changes in the metabolism of both cells and the organism^1,2. Pancreatic ductal adenocarcinoma (PDAC) is associated with wasting of peripheral tissues, a metabolic syndrome that lowers quality of life and has been proposed to decrease survival of patients with cancer^3,4. Tissue wasting is a multifactorial disease and targeting specific circulating factors to reverse this syndrome has been mostly ineffective in the clinic^5,6. Here we show that loss of both adipose and muscle tissue occurs early in the development of pancreatic cancer. Using mouse models of PDAC, we show that tumour growth in the pancreas but not in other sites leads to adipose tissue wasting, suggesting that tumour growth within the pancreatic environment contribu

SUBMITTER: Danai LV 

PROVIDER: S-EPMC6112987 | biostudies-literature | 2018 Jun

REPOSITORIES: biostudies-literature