Functional Foxp3 polymorphisms and the susceptibility to cancer: An update meta-analysis.

ABSTRACT:

Background

Forkhead box P3 (Foxp3) plays important roles in the development and pathogensis of cancer. To investigate the association of 3 polymorphisms of Foxp3 (rs3761548, rs 3761549 and rs2280883) and cancer risk, an updated meta-analysis was performed.

Methods

Around 11 studies including 4344 cancer patients and 4665 healthy controls were selected for this meta-analysis. There were nine studies with 3783 cases and 4096 controls for rs3761548, 4 studies with 1669 cases and 1613 controls for rs3761549 and 4 studies with 1821 cases and 1799 controls for rs2280883. Odds radios (ORs) and 95% confidence intervals (CIs) were used to evaluate the cancer risk.

Results

Meta-analysis showed that rs3761548 was associated with an increased cancer risk in the overall population

SUBMITTER: Cheng Z 

PROVIDER: S-EPMC6113014 | biostudies-literature | 2018 Aug

REPOSITORIES: biostudies-literature