Development of target-specific liposomes for delivering small molecule drugs after reperfused myocardial infarction.

ABSTRACT: Although reperfusion is essential in restoring circulation to ischemic myocardium, it also leads to irreversible events including reperfusion injury, decreased cardiac function and ultimately scar formation. Various cell types are involved in the multi-phase repair process including inflammatory cells, vascular cells and cardiac fibroblasts. Therapies targeting these cell types in the infarct border zone can improve cardiac function but are limited by systemic side effects. The aim of this work was to develop liposomes with surface modifications to include peptides with affinity for cell types present in the post-infarct myocardium. To identify peptides specific for the infarct/border zone, we used in vivo phage display methods and an optical imaging approach: fluorescence molecular tomogr

SUBMITTER: Dasa SSK 

PROVIDER: S-EPMC6113056 | biostudies-literature | 2015 Dec

REPOSITORIES: biostudies-literature